São Francisco do Guaporé is a municipality located in the Brazilian state of Rondônia. Its population was 20,681 (2020) and its area is 10,960 km.
The municipality contains 9% of the 36,442 hectares (90,050 acres) Serra dos Reis State Park. It contains 86% of the 2,244 hectares (5,550 acres) Serra dos Reis A State Park, created in 1996. It holds part of the 615,771 hectares (1,521,600 acres) Guaporé Biological Reserve, a strictly protected conservation unit.
